Med. Weter. 71 (6), 345-348, 2015
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| Kandefer-Gola M., Nowak M., Dzimira S., Janus I., Ciaputa R., Madej J.A. |
| COX-2 and mPGES-1 expression in canine mast cell tumours |
| COX-2 and mPGES-1 participate in the development of tumours and play a key role in their progression by impacting cell proliferation, apoptosis and neoangiogenesis. The aim of the study was to assess the expression of COX-2 and mPGES-1 in mast cell tumours. The existence of correlation between the histologic malignancy of the tumour and the expression of the proteins was verified through statistical analysis. Fifteen canine skin mast cell tumours were used in the study. Tissue sections were stained with H&E to determine their histologic grade. Subsequently, immunohistochemical staining of COX-2 and mPGES was carried out. A cytoplasmic reaction was observed in all tumours. Statistical analysis revealed a strong, positive correlation (p<0.05) between the two markers and the grade of the tumour. Both markers may be used effectively in the diagnosis of skin mast cell tumours in dogs. |
| Key words: COX-2, dog, mast cell tumour, mPGES-1 |