Medycyna Wet. 64 (2), 219-222, 2008
| Noszczyk-Nowak A., Skrzypczak P., Biały D., Nicpoń J., Mazurek W. |
| Model of experimental atherosclerosis of iliac arteries in rabbits |
| The aim of the study was to elaborate an effective method of triggering iliac artery atherosclerosis in rabbits. The authors applied a diet rich in fat, not based on cholesterol. Investigations were performed on 18 White New Zealand breed rabbits. After 3 weeks of adjustment, morphological and biochemical blood analysis was carried out: ALT activity, AST activity, urea, creatynine, cholesterol and its fraction (LDL, HDL), triglycerides (TGL), bilirubin and protein. Next, a diet rich in fat with 7% arachnid oil was administered to the rabbits. After 8 weeks the blond test was carried out again and indicated a significant increase in cholesterol concentration and LDL, following which the procedure of injuring the iliac artery was performed. Control blood analysis and iliac arteriography were performed after 12 weeks. A significant continuous increase in cholesterol concentration and LDL in the biochemical blood analysis was observed. Angiography indicated the narrowing of both iliac arteries in 12 rabbits (66.6%) and the narrowing of one artery in 6 rabbits (33.3%). Injuring the endothelium of the iliac arteries by means of a balloon used for angioplasty in hypercholestero-lemia leads to narrowing the vessel lumen. This method of experimental atherosclerosis in vessels is a good one for further research into this pathology. |
| Keywords: rabbit, atherosclerosis |